Downregulation of MHC class I expression by influenza A and B viruses

M Koutsakos; HEG McWilliam; TE Aktepe; S Fritzlar; PT Illing; NA Mifsud; AW Purcell; S Rockman; PC Reading; JP Vivian; J Rossjohn; AG Brooks; JM Mackenzie; JD Mintern; JA Villadangos; THO Nguyen; K Kedzierska

Journal article

Downregulation of MHC class I expression by influenza A and B viruses

M Koutsakos, HEG McWilliam, TE Aktepe, S Fritzlar, PT Illing, NA Mifsud, AW Purcell, S Rockman, PC Reading, JP Vivian, J Rossjohn, AG Brooks, JM Mackenzie, JD Mintern, JA Villadangos, THO Nguyen, K Kedzierska

Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2019

DOI: 10.3389/fimmu.2019.01158

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Abstract

Manipulation of the MHC-I presentation pathway, and thus limiting MHC-I cell surface expression, is used by many viruses to evade immune recognition. In particular, downregulation of MHC-I molecules at the cell surface can reduce the ability of CD8+ T cells to recognize viral peptides presented by MHC-I molecules and thereby delay viral clearance by CD8+ T cells. To date, MHC-I downregulation by influenza viruses has not been reported. Given that influenza virus infections are a global health concern and that CD8+ T cells play an important role in promoting influenza virus clearance and recovery from influenza disease, we investigated whether influenza A and B viruses (IAV, IBV) downregulate..

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University of Melbourne Researchers

Marios Koutsakos Author

Hamish McWilliam Author

Turgut Aktepe Author

Steven Rockman Author

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Grants

Awarded by Department of Health, Australian Government

Funding Acknowledgements

The Australian National Health and Medical Research Council (NHMRC) NHMRC Program Grant (1071916) to KK supported this work. MK is a recipient of Melbourne International Research Scholarship and Melbourne International Fee Remission Scholarship. KK is an NHMRC Senior Research Level B Fellow. The Melbourne WHO Collaborating Centre for Reference Research on Influenza is supported by the Australian Government Department of Health. HM is supported by an ARC Discovery Early Career Researcher Award (#DE170100575). JV is supported by a NHMRC Principal Research Fellowship and Program Grant (1163090) and by a Australian Research Council Discovery Project Grant (170102471). AP is supported by an NHMRC Principal Research Fellowship (1137739) and an NHMRC Project grant (1085018) to AP and NM. PI was supported by NHMRC Peter Doherty Fellowship (1072159).